Recombinant Rabbit monoclonal primary
Recombinant NUR77 Monoclonal Antibody (ET1703-97)
Rat brain cells lysates, HepG2, NIH-3T3, Hela, human liver tissue, human colon cancer tissue, human breast cancer tissue, mouse testis tissue, mouse ovarian tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Nuclear receptor subfamily 4 group A member 1
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Fetal muscle and adult liver, brain and thyroid.
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.; Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.
Nucleus. Cytoplasm. Mitochondrion. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27. Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid.
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).