Lane 1: MCF-7
Lane 2: 293T
Recombinant Rabbit monoclonal primary
Recombinant NSD3 Monoclonal Antibody (ET1611-39)
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
DKFZp667H044 antibody; FLJ20353 antibody; Histone lysine N methyltransferase NSD3 antibody; Histone-lysine N-methyltransferase NSD3 antibody; MGC126766 antibody; MGC142029 antibody; NSD 3 antibody; NSD3_HUMAN antibody; Nuclear set domain containing 3 antibody; Nuclear SET domain containing protein 3 antibody; Nuclear SET domain-containing protein 3 antibody; pp14328 antibody; Protein whistle antibody; Whistle antibody; WHSC1 like protein 1 antibody; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine antibody; WHSC1-like protein 1 antibody; WHSC1L1 antibody; WHSC1L1 protein antibody; Wolf Hirschhorn syndrome candidate 1 like 1 antibody; Wolf-Hirschhorn syndrome candidate 1-like protein 1 antibody
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
The deduced 1,437 amino acid NSD3 protein contains two PWWP domains involved in protein-protein interactions, five PHD-type zinc finger motifs found in chromatin-associated proteins, a SAC (SET-associated cys-rich) domain, a SET domain and a C-terminal C5HCH domain. Two NSD3 variants have been identified. The short variant comprised of 645 amino acids, arises from alternative polyadenylation and exon splicing and contains a single PWWP domain. A longer NSD3 variant, which is only expressed in HeLa cells, is comprised of 1,388 amino acid residues. The human WHSC1L1 gene, which encodes the NSD3 protein, shares 68% and 55% identity with mouse Nsd1 and human WHSC1, respectively. Highest expression of NSD3 is observed in brain, heart and skeletal muscle tissues; lower levels of NSD3 expression are observed in the liver and lungs.