Recombinant Rabbit monoclonal primary
Recombinant Noxa Monoclonal Antibody (ET1704-35)
Human liver tissue, human spleen tissue, human kidney tissue, Jurkat.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Adult T cell leukemia derived PMA responsive antibody; APR antibody; APR_HUMAN antibody; ATL-derived antibody; Immediate early response protein APR antibody; Immediate-early-response protein APR antibody; NOXA antibody; Phorbol 12 myristate 13 acetate induced protein 1 antibody; Phorbol-12-myristate-13-acetate-induced protein 1 antibody; PMA induced protein 1 antibody; PMA-induced protein 1 antibody; PMA-responsive gene antibody; Pmaip1 antibody; Protein Noxa antibody
Belongs to the PMAIP1 family.
Highly expressed in adult T-cell leukemia cell line.
Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis) under a broad range of physiological conditions. Bcl-2, Bcl-xL, and several related proteins inhibit apoptosis, whereas other members of the Bcl-2 family, such as Bax and Bak, enhance cell death. NOXA, a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. Murine cells constitutively express NOXA mRNA in small amounts in various organs; X-ray irradiation increases NOXA mRNA and protein expression levels. In human cells, NOXA, alternatively designated PMA-induced protein 1 or APR, displays high expression in the adult T cell leukemia cell line IKD, where it may function as an immediate-early-response gene. The NOXA protein selectively localizes to mitochondria.