Lane 1: A549
Lane 2: Mouse spleen tissue
Recombinant Rabbit monoclonal primary
Recombinant Nesprin 1 Monoclonal Antibody (ET7107-28)
A549, mouse spleen tissue lysate, C2C12, HUVEC, rat brain tissue, human tonsil tissue, human colon cancer tissue, human kidney tissue, mouse fallopian tubes tissue, Daudi.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
8B antibody; ARCA1 antibody; C6orf98 antibody; CPG2 antibody; CPG2 full length antibody; dJ45H2.2 antibody; EDMD4 antibody; Enaptin antibody; Myne-1 antibody; MYNE1 antibody; Myocyte nuclear envelope protein 1 antibody; Nesp1 antibody; Nesprin-1 antibody; Nuclear envelope spectrin repeat protein 1 antibody; SCAR8 antibody; Spectrin repeat containing nuclear envelope 1 antibody; Synaptic nuclear envelope protein 1 antibody; Synaptic nuclei expressed gene 1 antibody; Syne-1 antibody; SYNE1 antibody; SYNE1_HUMAN antibody; SYNE1B antibody
Belongs to the nesprin family.
Expressed in HeLa, A431, A172 and HaCaT cells (at protein level). Widely expressed. Highly expressed in skeletal and smooth muscles, heart, spleen, peripheral blood leukocytes, pancreas, cerebellum, stomach, kidney and placenta. Isoform GSRP-56 is predominantly expressed in heart and skeletal muscle (at protein level).
The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.