Recombinant Rabbit monoclonal primary
Recombinant NDRG1 Monoclonal Antibody (ET1705-20)
SW480 cell lysate, mouse eye tissue lysate, MCF-7, human colon cancer tissue, human prostate tissue, human placenta tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
42 kDa antibody; Anti GC4 antibody; cap43 antibody; cmt4d antibody; Differentiation related gene1 protein antibody; Differentiation-related gene 1 protein antibody; Drg 1 antibody; DRG-1 antibody; drg1 antibody; gc4 antibody; GC4 antibody; antibody; hmsnl antibody; Human mRNA for RTP complete cds antibody; N myc downstream regulated gene 1 antibody; N myc downstream regulated gene 1 protein antibody; N-myc downstream-regulated gene 1 protein antibody; Ndr 1 antibody; ndr1 antibody; NDRG 1 antibody; Ndrg1 antibody; NDRG1 protein antibody; NDRG1_HUMAN antibody; Nickel specific induction protein antibody; Nickel specific induction protein Cap43 antibody; Nickel-specific induction protein Cap43 antibody; nmsl antibody; Nmyc downstream regulated antibody; Nmyc downstream regulated gene1 antibody; Nmyc downstream regulated gene1 protein antibody; Protein NDRG1 antibody; Protein regulated by oxygen 1 antibody; Protein regulated by oxygen1 antibody; Proxy1 antibody; Reduced in tumor antibody; Reducin antibody; Reducing agents and tunicamycin responsive protein antibody; Reducing agents and tunicamycin-responsive protein antibody; Rit42 antibody; RTP antibody; targ1 antibody; TDD5 antibody; tdds antibody; Tunicamycin responsive protein antibody
Belongs to the NDRG family.
Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.
Cytoplasm. Nucleus. Cell membrane.
The N-myc downstream regulated gene (NDRG) family is comprised of four members, NDRG1 (also designated Drg1, RTP, rit42, Cap43 and Ndr1), NDRG2, NDRG3 and NDRG4, which share 57-65% homology. The NDRG1 gene, which maps to human chromosome 8q24.22, is evolutionarily conserved and is similarly regulated in humans, mice and rats . Like NDRG2 and NDRG3, NDRG1 is ubiquitously expressed, but it is expressed most prominently in placental membranes and prostate, kidney, small intestine and ovary tissue. NDRG1 gene expression is induced by several compounds, including nickel, and produces a protein involved in stress responses, hormone responses, cell growth and differentiation. The gene encoding NDRG3 maps to human chromosome 20q11.23 and is predominantly expressed in testis, prostate and ovary, which suggests it may play a role in spermatogenesis.