Recombinant Rabbit monoclonal primary
Recombinant MyD88 Monoclonal Antibody (ET1610-81)
HepG2, A549, MCF-7, human tonsil tissue, human kidney tissue, Hela.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Mutant myeloid differentiation primary response 88 antibody; MYD 88 antibody; Myd88 antibody; MYD88_HUMAN antibody; MYD88D antibody; Myeloid differentiation marker 88 antibody; Myeloid differentiation primary response 88 antibody; Myeloid differentiation primary response gene (88) antibody; Myeloid differentiation primary response gene 88 antibody; Myeloid differentiation primary response gene antibody; Myeloid differentiation primary response protein MyD88 antibody; OTTHUMP00000161718 antibody; OTTHUMP00000208595 antibody; OTTHUMP00000209058 antibody; OTTHUMP00000209059 antibody; OTTHUMP00000209060 antibody
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.
Interleukin-1 (IL-1)-induced activation of the NFκB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptor-associated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.