Lane 1: A549 cell lysate
Lane 2: PC-12 cell lysate
Lane 3: Hela cell lysate
Lane 4: mouse kidney tissue lysate
Recombinant Rabbit monoclonal primary
Recombinant MVP Monoclonal Antibody (ET1705-69)
A549 cell lysate, PC-12 cell lysate, Hela cell lysate, mouse kidney tissue lysate, human colon carcinoma tissue, human stomach carcinoma tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
LRP antibody; Lung resistance related protein antibody; Lung resistance-related protein antibody; Major vault protein antibody; Major vault protein, rat, homolog of antibody; MVP antibody; MVP_HUMAN antibody; testicular secretory protein Li 30 antibody; VAULT 1 antibody; VAULT1 antibody
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Phosphorylated on Tyr residues after EGF stimulation.; Dephosphorylated by PTPN11.
Cytoplasm. Nucleus. Membrane.
Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.