PRODUCT CODE: ET1704-56

Recombinant MRP1 Monoclonal Antibody (ET1704-56)

  • Recombinant

Applications

  • WB

  • IHC-P

  • FC

REACTIVITY

  • Human

Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-MRP1 antibody. Counter stained with
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-MRP1 antibody. Counter stained with
  • Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MRP1 antibody. Counter stained with hematoxylin.
  • Flow cytometric analysis of Hela cells with MRP1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-MRP1 antibody. Counter stained with

Applications

  • WB

  • IHC-P

  • FC

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant MRP1 Monoclonal Antibody (ET1704-56)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human tonsil tissue, human pancreas tissue, Hela.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JA93-03

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

171 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

Multidrug resistance-associated protein 1

GENE NAME

ABCC1

SYNONYMS

LTC4 transporter, ABCC1, MRP, MRP1

SEQUENCE SIMILARITIES

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

TISSUE SPECIFICITY

Lung, testis and peripheral blood mononuclear cells.

SUBCELLULAR LOCATION

Cell membrane; Multi-pass membrane protein.

FUNCTION

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).