Recombinant Rabbit monoclonal primary
Recombinant MMP14 Monoclonal Antibody (ET1606-48)
CRC, BT-20, human breast carcinoma tissue, human uterus tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
MMP-14, MTMMP1, MT1-MMP, MT1MMP, MT-MMP 1
Belongs to the peptidase M10A family.
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
The precursor is cleaved by a furin endopeptidase.; Tyrosine phosphorylated by PKDCC/VLK.
Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
Lin, Yinuo et al.
Exosomes derived from HeLa cells break down vascular integrity by triggering endoplasmic reticulum stress in endothelial cells. | Journal of Extracellular Vesicles