Recombinant Rabbit monoclonal primary
Recombinant MMP11 Monoclonal Antibody (ET1611-33)
293T cell lysates, SW480, MCF-7, A549, human spleen tissue, human breast carcinoma tissue, mouse spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Matrix Metalloproteinase 11 antibody; Matrix metalloproteinase-11 antibody; MMP-11 antibody; Mmp11 antibody; MMP11_HUMAN antibody; SL 3 antibody; SL-3 antibody; SL3 antibody; ST3 antibody; STMY3 antibody; Stromelysin 3 antibody; Stromelysin III antibody; Stromelysin-3 antibody
Belongs to the peptidase M10A family.
Specifically expressed in stromal cells of breast carcinomas.
The precursor is cleaved by a furin endopeptidase.
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also called stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.