Recombinant Rabbit monoclonal primary
Recombinant Metabotropic glutamate receptor 5 Monoclonal Antibody (ET1609-36)
PC-12 cell lysates, JAR, PC-12, SHG-44, rat brain tissue, mouse brain tissue, SH-SY5Y.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Metabotropic glutamate receptor 5
Glutamate receptor metabotropic 5 antibody; GPRC1E antibody; Grm5 antibody; GRM5_HUMAN antibody; Metabotropic glutamate receptor 5 antibody; Metabotropic glutamate receptor 5 variant F antibody; Metabotropic glutamate receptor 5 variant G antibody; Metabotropic glutamate receptor 5 variant H antibody; mGlu5 antibody; mGluR5 antibody; PPP1R86 antibody; Protein phosphatase 1 regulatory subunit 86 antibody
Belongs to the G-protein coupled receptor 3 family.
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-5, which can interact with SIAH-1, RyR-1, RyR-2, ITPR1, Shank 1, Shank 3 and GRASP, acts as a receptor for glutamate. The PPXXf motif of mGluR-5 binds to HOM1, HOM2 and HOM3.