Recombinant Rabbit monoclonal primary
Recombinant MEK5 Monoclonal Antibody (ET1612-34)
Hela cell lysates, Hela, A431, SW480.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Dual specificity mitogen activated protein kinase kinase 5 antibody; Dual specificity mitogen-activated protein kinase kinase 5 antibody; EC 188.8.131.52 antibody; HsT17454 antibody; MAP kinase kinase 5 antibody; MAP kinase kinase MEK5b antibody; MAP2K5 antibody; MAPK/ERK kinase 5 antibody; MAPKK 5 antibody; MAPKK5 antibody; MEK 5 antibody; mitogen-activated protein kinase kinase 5 antibody; MKK5 antibody; MP2K5_HUMAN antibody; PRKMK5 antibody; Protein kinase, mitogen-activated, kinase 5 antibody; SAPKK5 antibody; SKK5 antibody
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.; Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
Spindle, Cytosol, nucleus, cytoplasm.
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.