Lane 1: Hela
Lane 2: Jurkat
Recombinant Rabbit monoclonal primary
Recombinant MEK3+MEK6 Monoclonal Antibody (ET1701-48)
Jurkat, NIH/3T3, Hela, HepG2, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Dual specificity mitogen activated protein kinase kinase 6 antibody; Dual specificity mitogen-activated protein kinase kinase 3 antibody; MAP kinase kinase 3 antibody; MAP kinase kinase 6 antibody; map2k3 antibody; MAP2K6 antibody; MAPK/ERK kinase 3 antibody; MAPK/ERK kinase 6 antibody; MAPKK 3 antibody; MAPKK 6 antibody; MAPKK3 antibody; MAPKK6 antibody; MEK 3 antibody; MEK 6 antibody; Mitogen activated protein kinase kinase 3 antibody; Mitogen activated protein kinase kinase 6 antibody; MKK3 antibody; MKK6 antibody; MP2K3_HUMAN antibody; PRKMK3 antibody; PRKMK6 antibody; Protein kinase, mitogen activated, kinase 6 (MAP kinase kinase 6) antibody; SAPK kinase 2 antibody; SAPKK 3 antibody; SAPKK-2 antibody; SAPKK2 antibody; SAPKK3 antibody; Stress activated protein kinase kinase 3 antibody; Stress-activated protein kinase kinase 2 antibody
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.; Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.