Lane 1: Jurkat
Lane 2: Hela
Lane 3: 293T
Recombinant Rabbit monoclonal primary
Recombinant MEK2 Monoclonal Antibody (ET1612-6)
NIH/3T3, MCF-7, Hela, 293T, human liver cancer tissue, human spleen tissue, human breast carcinoma tissue, mouse lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Cardiofaciocutaneous syndrome antibody; CFC syndrome antibody; CFC4 antibody; Dual specificity mitogen activated protein kinase kinase 2 antibody; Dual specificity mitogen-activated protein kinase kinase 2 antibody; ERK activator kinase 2 antibody; FLJ26075 antibody; MAP kinase kinase 2 antibody; map2k2 antibody; MAPK / ERK kinase 2 antibody; MAPK/ERK kinase 2 antibody; MAPKK 2 antibody; MAPKK2 antibody; MEK 2 antibody; MEK2 antibody; Microtubule associated protein kinase kinase 2 antibody; Mitogen activated protein kinase kinase 2 antibody; Mitogen activated protein kinase kinase 2 p45 antibody; MKK 2 antibody; MKK2 antibody; MP2K2_HUMAN antibody; OTTHUMP00000165826 antibody; OTTHUMP00000165827 antibody; PRKMK 2 antibody; PRKMK2 antibody
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).; Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.
Wang, Jing et al.
The construction of intrahepatic cholangiocarcinoma model in zebrafish. | Scientific Reports