Lane 1: Mouse testis
Lane 2: SH-SY-5Y
Lane 3: Mouse lung
Recombinant Rabbit monoclonal primary
Recombinant MEIS2 Monoclonal Antibody (ET7107-04)
Mouse testis tissue lysate, SH-SY-5Y, human kidney tissue lysate, mouse lung tissue lysate, K562.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Homeobox protein Meis2 antibody; HsT18361 antibody; Meis (mouse) homolog 2 antibody; Meis homeobox 2 antibody; Meis homolog 2 antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse) antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibody; Meis1 related gene 1 antibody; Meis1 related protein 1 antibody; Meis1-related protein 1 antibody; MEIS2 antibody; MEIS2_HUMAN antibody; MGC2820 antibody; MRG1 antibody; TALE homeobox protein Meis2 antibody
Belongs to the TALE/MEIS homeobox family.
Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate.
Profilins regulate Actin polymerization by binding to and sequestering the Actin monomer. Profilins act as a nucleotide exchange factor that charges Actin with ATP after binding the Actin monomer through a 1:1 stoichiometric relationship. Human Profilin-1 and Profilin-2 are encoded by two separate genes mapping to chromosomes 17p13.2 and 3q25.1, respectively. Both Profilin-1 and Profilin-2 are abundantly expressed in kidney. Profilin-1 is highly expressed in lung, liver, placenta and kidney while Profilin-2 is highly expressed in brain and skeletal muscle. In axonal and dendritic processes of mouse brain, Profilins co-localize with dynamin I and synapsin. Profilin may play a role in mediating cell adhesion. The overexpression of Profilin in endothelial cells results in increased adhesion to Fibronectin. In food allergy, plant Profilin is considered a pan-allergen. Case studies indicate individuals with allergies to various foods including celery, carrots, zucchini and peanuts are actually sensitive to the Profilin proteins in these foods.