Recombinant MEIS1 Monoclonal Antibody (ET1704-84)

Western blot analysis of MEIS1 on human skeletal muscle (1) and mouse brain (2) tissue lysate using anti-MEIS1 antibody at 1/1,000 dilution.

Applications

REACTIVITY

Human
Mouse
Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant MEIS1 Monoclonal Antibody (ET1704-84)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human skeletal muscle tissue, mouse brain tissue, K562.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JA13-26

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

47 kDa

Isotype

IgG

APPLICATION DILUTION

WB
1:500

FC
1:50-1:100

TARGET

UNIPROT #

O00470

PROTEIN NAME

MEIS1

SYNONYMS

Homeo box protein Meis1 antibody; Homeobox protein Meis1 antibody; Leukemogenic homolog protein antibody; MEIS 1 antibody; Meis homeo box 1 antibody; Meis homeobox 1 antibody; Meis1 antibody; Meis1 mouse homolog antibody; Meis1 myeloid ecotropic viral integration site 1 homolog antibody; Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody; MEIS1 protein antibody; MEIS1_HUMAN antibody; MGC43380 antibody; Myeloid ecotropic viral integration site 1 homolog antibody; WUGSC:H NH0444B04.1 antibody

SEQUENCE SIMILARITIES

Belongs to the TALE/MEIS homeobox family.

TISSUE SPECIFICITY

Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.