Recombinant Rabbit monoclonal primary
Recombinant MEIS1 Monoclonal Antibody (ET1704-84)
Human skeletal muscle tissue, mouse brain tissue, K562.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Homeo box protein Meis1 antibody; Homeobox protein Meis1 antibody; Leukemogenic homolog protein antibody; MEIS 1 antibody; Meis homeo box 1 antibody; Meis homeobox 1 antibody; Meis1 antibody; Meis1 mouse homolog antibody; Meis1 myeloid ecotropic viral integration site 1 homolog antibody; Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody; MEIS1 protein antibody; MEIS1_HUMAN antibody; MGC43380 antibody; Myeloid ecotropic viral integration site 1 homolog antibody; WUGSC:H NH0444B04.1 antibody
Belongs to the TALE/MEIS homeobox family.
Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.