Lane 1: Mouse thymus tissue
Lane 2: SiHa
Recombinant Rabbit monoclonal primary
Recombinant MCM5 Monoclonal Antibody (ET7107-15)
Recombinant protein within c terminal human mcm5.
Mouse thymus tissue lysate, SiHa, human tonsil tissue, human placenta tissue, mouse testis tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
DNA replication licensing factor MCM5
Belongs to the MCM family.
Nucleus. Cytoplasm, cytosol.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.