Lane 1: MCF-7 cell lysate
Lane 2: SW480 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant LYVE1 Monoclonal Antibody (ET1702-29)
MCF-7 cell lysate, SW480 cell lysate, A431, HUVEC, SW480, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Cell surface retention sequence-binding protein 1 antibody; CRSBP 1 antibody; CRSBP-1 antibody; CRSBP1 antibody; extracellular link domain containing 1 antibody; extracellular link domain-containing 1 antibody; Extracellular link domain-containing protein 1 antibody; HAR antibody; Hyaluronic acid receptor antibody; Lymphatic endothelium specific hyaluronan receptor antibody; lymphatic vessel endothelial hyaluronan receptor 1 antibody; Lymphatic vessel endothelial hyaluronic acid receptor 1 antibody; LYVE 1 antibody; LYVE-1 antibody; LYVE1 antibody; LYVE1_HUMAN antibody; XLKD1 antibody
Mainly expressed in endothelial cells lining lymphatic vessels.
Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) is expressed on the cell surface as a protein that is reduced by glycosidase treatment. LYVE-1 is abundant in spleen, lymph node, heart, lung and fetal liver, and is less abundant in appendix, bone marrow, placenta, muscle and adult liver. Expression of LYVE-1 is largely restricted to endothelial cells lining lymphatic vessels and splenic sinusoidal endothelial cells. LYVE-1 binds to both soluble and immobilized hyaluronan (HA) with greater specificity than HCAM. Like HCAM, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike HCAM, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE-1 is used as a marker to study tumor lymphangiogenesis, which is an important area of investigation.