Lane 1: mouse liver tissue lysate
Lane 2: mouse brain tissue lysate
Lane 3: mouse lung tissue lysate
Lane 4: human liver tissue lysate
Lane 5: HepG2 cell lysate
Lane 6: human lung tissue lysate
Recombinant Rabbit monoclonal primary
Recombinant LRP1 Monoclonal Antibody (ET1601-1)
Synthetic peptide within human lrp1 aa 4480-4520(85kda).
Mouse liver tissue lysate, mouse brain tissue lysate, mouse lung tissue lysate, human liver tissue lysate, HepG2 cell lysate, human lung tissue lysate, Hela, MCF-7, HUVEC, human lung tissue, mouse brain tissue, mouse liver tissue, human liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Prolow-density lipoprotein receptor-related protein 1
LRP-1, A2MR, APOER, CD91
Belongs to the LDLR family.
Most abundant in liver, brain and lung.
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.; The N-terminus is blocked.; Phosphorylated on serine and threonine residues.; Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.; Postsynaptic Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor.; (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.