Lane 1: Jurkat
Lane 2: Mouse brain
Lane 3: Human fetal brain
Recombinant Rabbit monoclonal primary
Recombinant LOX Monoclonal Antibody (ET1706-31)
Jurkat, mouse brain tissue lysate, human fetal brain tissue, Zebrafish tissue lysates, Hela, HUVEC, SH-SY5Y, rat skeletal tissue, human kidney tissue, human placenta tissue, mouse heart tissue, Hela.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Belongs to the lysyl oxidase family.
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.; Proteolytically cleaved by BMP1 which removes the propeptide. Also proteolytically cleaved by ADAMTS2 and ADAMTS14, but not by ADAMTS3, at an additional cleavage site downstream of the BMP1 cleavage site. The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity). Cleavage by BMP1 to remove the propeptide does not increase enzymatic activity but increases binding to collagen. Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity.; Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen.
Secreted. Secreted, extracellular space.
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).