Recombinant Rabbit monoclonal primary
Recombinant Lipoprotein lipase Monoclonal Antibody (ET1704-48)
Human placenta tissue lysate, human ileum tissue, human pancreas tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
EC 3.1.1 antibody; EC 188.8.131.52 antibody; HDLCQ11 antibody; LIPD antibody; LIPL_HUMAN antibody; Lipoprotein lipase antibody; LPL antibody; LPL protein antibody; MGC137861 antibody
Belongs to the AB hydrolase superfamily. Lipase family.
Detected in blood plasma. Detected in milk (at protein level).
Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
Cell membrane. Secreted.
The Lipase gene family belongs to one of the most robust genetic superfamilies found in living organisms, which includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Members of the AB hydrolase subfamily include hepatic lipase (HL), endothelial lipase (EL), lipoprotein lipase (LPL) and pancreatic lipase (PL). HL balances the composition and transport of lipoproteins in human plasma. Synthesized in endothelial cells, EL hydrolyzes high density lipoproteins. LPL, a homodimer attached to the membrane by a GPI-anchor, mediates the hydrolysis of triglycerides of very low density lipoproteins and circulating chylomicrons. Defects in LPL may cause chylomicronemia syndrome or a form of lipoprotein lipase deficiency characterized by hypertriglyceridemia.