PRODUCT CODE: ET1703-51

Recombinant L1CAM Monoclonal Antibody (ET1703-51)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution.<br />
Positive control: <br />
Line 1: Hela <br />
Line 2: human brain
  • Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution.<br />
Positive control: <br />
Line 1: Hela <br />
Line 2: human brain
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution.
Positive control:
Line 1: Hela
Line 2: human brain

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant L1CAM Monoclonal Antibody (ET1703-51)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Hela, human brain, human kidney tissue, human thyroid tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM11-05

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

85/250 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

Neural cell adhesion molecule L1

GENE NAME

L1CAM

SYNONYMS

N-CAM-L1, NCAM-L1, L1CAM

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

SUBCELLULAR LOCATION

Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites.

FUNCTION

Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.