PRODUCT CODE: ET1703-51

Recombinant L1CAM Monoclonal Antibody (ET1703-51)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution.<br />
 Positive control: <br />
 Line 1: Hela <br />
 Line 2: human brain
  • Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution.<br />
 Positive control: <br />
 Line 1: Hela <br />
 Line 2: human brain
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution.
Positive control:
Line 1: Hela
Line 2: human brain

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant L1CAM Monoclonal Antibody (ET1703-51)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Hela, human brain, human kidney tissue, human thyroid tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM11-05

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

85/250 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

L1CAM

SYNONYMS

Antigen identified by monoclonal antibody; R1 antibody; CAML1 antibody; CD171 antibody; CD171 antigen antibody; HSAS antibody; HSAS1 antibody; Hyd antibody; L1 antibody; L1 cell adhesion molecule antibody; L1-NCAM antibody; L1cam antibody; L1CAM_HUMAN antibody; MASA antibody; MIC5 antibody; N CAML1 antibody; N-CAM-L1 antibody; NCAM-L1 antibody; NCAML1 antibody; Nerve-growth factor-inducible large external glycoprotein antibody; Neural cell adhesion molecule L1 antibody; NILE antibody; OTTHUMP00000025992 antibody; S10 antibody; SPG1 antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play an important role in embryogenesis and development. Neuronal cell adhesion molecule (NCAM) expression is observed in a variety of human tumors, including neuroblastomas, rhabdomyosarcomas, Wilm's tumors, Ewing's sarcomas and some primitive myeloid malignancies. The NCAM-L1 adhesion molecule (CD171) plays an important role in axon guidance and cell migration in the nervous system. The presence of NCAM-L1 might contribute to tumor progression by promoting cell adhesion and migration and is known to be expressed by neurons, neuroblastomas and other malignant tumors.