PRODUCT CODE: ET1705-25

Recombinant KAT7 Monoclonal Antibody (ET1705-25)

  • Recombinant

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

Immunohistochemical analysis of paraffin-embedded mouse testes tissue using anti-KAT7 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse testes tissue using anti-KAT7 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded rat testes tissue using anti-KAT7 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse fallopian tubes tissue using anti-KAT7 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse testes tissue using anti-KAT7 antibody. Counter stained with hematoxylin.

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant KAT7 Monoclonal Antibody (ET1705-25)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Rat testes tissue, mouse testes tissue, mouse fallopian tubes tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM32-39

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

75 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500

  • IHC-P

  • 1:50-1:100

TARGET

UNIPROT #

PROTEIN NAME

KAT7

SYNONYMS

Hbo 1 antibody; HBO1 antibody; HBOa antibody; Histone acetyltransferase binding to hORC1 antibody; Histone acetyltransferase binding to ORC1 antibody; Histone acetyltransferase KAT7 antibody; Histone acetyltransferase MYST2 antibody; K(lysine) acetyltransferase 7 antibody; KAT 7 antibody; KAT7 antibody; Lysine acetyltransferase 7 antibody; MOZ antibody; MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody; MYST 2 antibody; MYST histone acetyltransferase 2 antibody; MYST protein 2 antibody; MYST-2 antibody; MYST2 antibody; MYST2_HUMAN antibody; SAS 2 antibody; SAS2 and TIP60 protein 2 antibody; TIP60 protein 2 antibody; YBF2/SAS3 antibody; ZC2HC7 antibody

SEQUENCE SIMILARITIES

Belongs to the MYST (SAS/MOZ) family.

TISSUE SPECIFICITY

Ubiquitously expressed, with highest levels in testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-50 and Ser-53 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation. Phosphorylation at Ser-50 and Ser-53 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites. Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1. Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).; Ubiquitinated at Lys-338, leading to proteasomal degradation. Ubiquitinated by the CRL4(DDB2) complex following phosphorylation by ATR, leading to its subsequent degradation.; Autoacetylation at Lys-432 is required for proper function.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.