Recombinant Rabbit monoclonal primary
Recombinant KAT7 Monoclonal Antibody (ET1705-25)
Rat testes tissue, mouse testes tissue, mouse fallopian tubes tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Hbo 1 antibody; HBO1 antibody; HBOa antibody; Histone acetyltransferase binding to hORC1 antibody; Histone acetyltransferase binding to ORC1 antibody; Histone acetyltransferase KAT7 antibody; Histone acetyltransferase MYST2 antibody; K(lysine) acetyltransferase 7 antibody; KAT 7 antibody; KAT7 antibody; Lysine acetyltransferase 7 antibody; MOZ antibody; MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody; MYST 2 antibody; MYST histone acetyltransferase 2 antibody; MYST protein 2 antibody; MYST-2 antibody; MYST2 antibody; MYST2_HUMAN antibody; SAS 2 antibody; SAS2 and TIP60 protein 2 antibody; TIP60 protein 2 antibody; YBF2/SAS3 antibody; ZC2HC7 antibody
Belongs to the MYST (SAS/MOZ) family.
Ubiquitously expressed, with highest levels in testis.
Phosphorylated at Ser-50 and Ser-53 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation. Phosphorylation at Ser-50 and Ser-53 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites. Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1. Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).; Ubiquitinated at Lys-338, leading to proteasomal degradation. Ubiquitinated by the CRL4(DDB2) complex following phosphorylation by ATR, leading to its subsequent degradation.; Autoacetylation at Lys-432 is required for proper function.
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.