Lane 1: MCF-7 cell lysate
Lane 2: SiHa cell lysate
Lane 1: U937 cell lysate
Lane 2: THP-1 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant JunB Monoclonal Antibody (ET1612-57)
MCF-7 cell lysate, SiHa cell lysate, U937 cell lysate, THP-1 cell lysate, Hela, HepG2, human tonsil tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Activator protein 1 antibody; AP 1 antibody; AP1 antibody; Jun B antibody; Jun B proto oncogene antibody; Jun B protooncogene antibody; Junb antibody; JunB proto oncogene antibody; JunB protoncogene 9 antibody; JunB protooncogene antibody; JUNB_HUMAN antibody; Transcription factor jun B antibody; Transcription factor jun-B antibody; Transcription factor junB antibody
Belongs to the bZIP family. Jun subfamily.
Ubiquitinated by ITCH, leading to its degradation.
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.