Lane 1: Hela cell lysate
Lane 2: PC-12 cell lysate
Lane 2: K562 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant JNK1+JNK2+JNK3 Monoclonal Antibody (ET1601-28)
Recombinant protein within human jnk1 aa 1-400.
Hela cell lysate, PC-12 cell lysate, K562 cell lysate, hybrid fish (crucian-carp) brain tissue lysates, NIH/3T3.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
C Jun kinase 2 antibody; c Jun N terminal kinase 1 antibody; c Jun N terminal kinase 2 antibody; c Jun N terminal kinase 3 antibody; c-Jun N-terminal kinase 1 antibody; JNK 46 antibody; JNK 55 antibody; JNK antibody; JNK-46 antibody; JNK1 antibody; JNK1A2 antibody; JNK2 antibody; JNK21B1/2 antibody; JNK2A antibody; JNK2ALPHA antibody; JNK2B antibody; JNK2BETA antibody; JNK3 alpha protein kinase antibody; JNK3 antibody; JNK3A antibody; Jun kinase antibody; JUN N terminal kinase antibody; MAP kinase 10 antibody; MAP kinase 8 antibody; MAP kinase 9 antibody; MAP kinase p49 3F12 antibody; MAPK 10 antibody; MAPK 8 antibody; MAPK 9 antibody; MAPK10 antibody; mapk8 antibody; MAPK9 antibody; Mitogen activated protein kinase 10 antibody; Mitogen activated protein kinase 8 antibody; Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody; Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody; Mitogen activated protein kinase 9 antibody; Mitogen-activated protein kinase 8 antibody; MK08_HUMAN antibody; p493F12 antibody; p54a antibody; p54aSAPK antibody; p54bSAPK antibody; PRKM10 antibody; PRKM8 antibody; PRKM9 antibody; SAPK antibody; SAPK(beta) antibody; SAPK1 antibody; SAPK1a antibody; SAPK1b antibody; SAPK1c antibody; Stress activated protein kinase 1 antibody; Stress activated protein kinase 1a antibody; Stress activated protein kinase 1b antibody; Stress activated protein kinase 1c antibody; Stress activated protein kinase beta antibody; Stress activated protein kinase JNK1 antibody; Stress activated protein kinase JNK2 antibody; Stress activated protein kinase JNK3 antibody; Stress-activated protein kinase 1c antibody; Stress-activated protein kinase JNK1 antibody
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2. May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1. Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity).
Cytoplasm, Nucleus, Membrane, Mitochondrion
c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.