Lane 1: PC-12
Lane 2: Jurkat
Lane 3: NIH-3T3
Recombinant Rabbit monoclonal primary
Recombinant JAK1 Monoclonal Antibody (ET1705-84)
PC-12, Jurkat, NIH-3T3, mouse colon tissue, mouse kidney tissue, SW480.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Tyrosine-protein kinase JAK1
JAK-1, JAK1A, JAK1B
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Autophosphorylated. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling.; Ubiquitinated by RNF125; leading to its degradation by the proteasome.
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.