UNIPROT #

P78504

PROTEIN NAME

Jagged1

SYNONYMS

AGS antibody; AHD antibody; AWS antibody; CD 339 antibody; CD339 antibody; CD339 antigen antibody; Headturner antibody; hJ1 antibody; Htu antibody; Jag 1 antibody; Jag1 antibody; JAG1_HUMAN antibody; Jagged 1 antibody; Jagged1 (Alagille syndrome) antibody; Jagged1 antibody; JAGL1 antibody; MGC104644 antibody; OTTHUMP00000030278 antibody; Protein jagged-1 antibody; Ser 1 antibody; Ser1 antibody; Serrate 1 antibody; Slalom antibody

TISSUE SPECIFICITY

Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

DEVELOPMENTAL STAGE

Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and expression is upregulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the Jagged1 gene.