PRODUCT CODE: ET1704-77

Recombinant IP3 Receptor Monoclonal Antibody (ET1704-77)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

Immunohistochemical analysis of paraffin-embedded mouse hippocampus tissue using anti-IP3 Receptor antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse hippocampus tissue using anti-IP3 Receptor antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse hippocampus tissue using anti-IP3 Receptor antibody. Counter stained with hematoxylin.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant IP3 Receptor Monoclonal Antibody (ET1704-77)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Mouse hippocampus tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JA11-35

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

314 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

Inositol 1,4,5-trisphosphate receptor type 1

GENE NAME

ITPR1

SYNONYMS

IP3R 1, InsP3R1, Type 1 InsP3 receptor, ITPR1, INSP3R1

SEQUENCE SIMILARITIES

Belongs to the InsP3 receptor family.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues.; Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity).; Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1.; Palmitoylated by ZDHHC6 in immune cells, leading to regulate ITPR1 stability and function.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Endoplasmic reticulum and secretory granules (By similarity).

FUNCTION

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).