Applications
-
IHC-P
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Recombinant Integrin alpha E Monoclonal Antibody (ET1611-27)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
Human tonsil tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SN62-06
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A affinity purified.
Isotype
IgG
APPLICATION DILUTION
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
Integrin alpha E
SYNONYMS
A530055J10 antibody; alpha-E1 antibody; alpha-M290 antibody; aM290 antibody; Antigen CD103 antibody; CD 103 antibody; CD103 antibody; CD103 antigen antibody; HML 1 antigen antibody; HML-1 antigen antibody; HML1 antigen antibody; Human mucosal lymphocyte antigen 1 antibody; Human mucosal lymphocyte antigen 1, alpha subunit antibody; Huminae antibody; Integrin alpha E heavy chain antibody; Integrin alpha E light chain antibody; Integrin alpha E, epithelial-associated antibody; Integrin alpha E1 antibody; Integrin alpha IEL antibody; Integrin alpha M290 antibody; Integrin alpha-E heavy chain antibody; Integrin alpha-IEL antibody; Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) antibody; Integrin, alpha E antibody; ITAE_HUMAN antibody; Itgae antibody; MGC141996 antibody; MGC183601 antibody; Mucosal lymphocyte 1 antigen antibody; Mucosal lymphocyte antigen 1 antibody
SEQUENCE SIMILARITIES
Belongs to the integrin alpha chain family.
TISSUE SPECIFICITY
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
SUBCELLULAR LOCATION
Membrane.
FUNCTION
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.