Lane 1: MCF-7 cell lysate
Lane 2: A431 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant Integrin alpha 2 Monoclonal Antibody (ET1611-57)
MCF-7 cell lysate, A431 cell lysate, A431, MCF-7, human colon carcinoma tissue, human breast carcinoma tissue, human kidney tissue, mouse colon tissue, mouse stomach tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Integrin alpha 2
BR antibody; CD 49b antibody; CD49 antigen like family member B antibody; CD49 antigen-like family member B antibody; CD49b antibody; CD49b antigen antibody; Collagen receptor antibody; DX5 antibody; Glycoprotein Ia deficiency included antibody; GP Ia antibody; GP Ia deficiency, included antibody; GPIa antibody; HPA 5 included antibody; HPA5 included antibody; Human platelet alloantigen system 5 antibody; Integrin alpha 2 antibody; Integrin alpha-2 antibody; Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor) antibody; ITA2_HUMAN antibody; ITGA2 antibody; Platelet alloantigen Br(a), included antibody; Platelet antigen Br antibody; Platelet glycoprotein GPIa antibody; Platelet glycoprotein Ia antibody; Platelet glycoprotein Ia/IIa antibody; Platelet membrane glycoprotein Ia antibody; Platelet receptor for collagen, deficiency of, included antibody; Very late activation protein 2 receptor alpha 2 subunit antibody; VLA 2 alpha chain antibody; VLA 2 antibody; VLA 2 subunit alpha antibody; VLA-2 subunit alpha antibody; VLA2 antibody; VLA2 receptor alpha 2 subunit antibody; VLAA2 antibody
Belongs to the integrin alpha chain family.
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The sixteen α and eight β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counter-receptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin α2 is responsible for adhesion of platelets and other cells to collagens. Modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix.