Applications
-
WB
-
IHC-P
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Recombinant Insulin Receptor R Monoclonal Antibody (ET1705-22)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
Human colon cancer tissue, human kidney tissue, human liver cancer tissue, mouse testis tissue, mouse kidney tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM22-38
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
80 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
Insulin Receptor R
SYNONYMS
INSRR antibody; INSRR_HUMAN antibody; Insulin receptor related receptor precursor antibody; Insulin receptor-related protein alpha chain antibody; Insulin receptor-related protein beta chain antibody; insulin receptor-related receptor antibody; IR R antibody; IR related receptor antibody; IR-related receptor antibody; IRR antibody; Sir r antibody; Sirr antibody
SEQUENCE SIMILARITIES
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
POST-TRANSLATIONAL MODIFICATION
Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
SUBCELLULAR LOCATION
Membrane.
FUNCTION
The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment.Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.