Recombinant Rabbit monoclonal primary
Recombinant IL1 beta Monoclonal Antibody (ET1701-39)
A431, Hela, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Catabolin antibody; H1 antibody; IL 1 antibody; IL 1 beta antibody; IL-1 beta antibody; IL1 BETA antibody; IL1B antibody; IL1B_HUMAN antibody; IL1F2 antibody; Interleukin 1 beta antibody; Interleukin-1 beta antibody; OAF antibody; OTTHUMP00000162031 antibody; Preinterleukin 1 beta antibody; Pro interleukin 1 beta antibody
Belongs to the IL-1 family.
Expressed in activated monocytes/macrophages (at protein level).
Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
Cytoplasm, Lysosome, extracellular exosome, Secreted.
Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.