Recombinant Rabbit monoclonal primary
Recombinant IgA Monoclonal Antibody (ET1703-10)
Human plasma lysates, HepG2, human tonsil tissue, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Hepatocellular carcinoma-associated protein TB6 antibody; Ig alpha 1 chain C region antibody; Ig alpha 2 chain C region antibody; IGHA antibody; IGHA1 antibody; IGHA2 antibody; Immunoglobulin heavy constant alpha 1 antibody; Immunoglobulin heavy constant alpha 2 A2m marker antibody; Immunoglobulin heavy constant alpha 2 antibody; PIgR antibody; Poly-Ig receptor antibody; polymeric immunoglobulin receptor antibody; polymeric immunoglobulin receptor Secretory component antibody
3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.; N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
Cell membrane, Secreted.
Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. The IgA heavy chain is an α-chain, and the light chains are either κ- or λ- chains. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces.