Line 1: Mouse heart
Line 2: Rat heart
Line 3: 293T
Recombinant Rabbit monoclonal primary
Recombinant IDH2 Monoclonal Antibody (ET1704-93)
293T, mouse heart tissue lysate, rat heart tissue lysate, human liver tissue, human prostate tissue, MCF-7.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
D2HGA2 antibody; ICD-M antibody; IDH antibody; IDH2 antibody; IDHM antibody; IDHP_HUMAN antibody; IDP antibody; IDPM antibody; Isocitrate dehydrogenase [NADP], mitochondrial antibody; Isocitrate dehydrogenase 2 (NADP+), mitochondrial antibody; mNADP-IDH antibody; NADP(+)-specific ICDH antibody; Oxalosuccinate decarboxylase antibody
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3.
IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), also designated NADP+-specific ICDH; isocitrate dehydrogenase, mitochondrial; and oxalosuccinate decarboxylase, is a 452 amino acid enzyme encoded by the human gene IDH2. IDH2 belongs to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains the supply of glutathione (GSH) in mitochondria. It is believed to play a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. IDH2 is found in the mitochondrion as a homodimer and can bind one magnesium or manganese ion per subunit.