Recombinant Rabbit monoclonal primary
Recombinant Id1 Monoclonal Antibody (ET1705-49)
293T, HepG2, Hela, A549, human tonsil tissue, human liver tissue, human colon tissue, human placenta tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
bHLHb24 antibody; Class B basic helix-loop-helix protein 24 antibody; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein) antibody; DNA binding protein inhibitor ID 1 antibody; DNA binding protein inhibitor ID1 antibody; DNA-binding protein inhibitor ID-1 antibody; Dominant negative helix loop helix protein antibody; ID 1 antibody; ID antibody; ID1 antibody; ID1_HUMAN antibody; Inhibitor of Differentiation 1 antibody; Inhibitor of DNA binding 1 antibody; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein antibody
Expression correlates with proliferation in some types of cells.
Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.