Lane 1: Rat spleen tissue
Lane 2: Rat heart tisse
Lane 3: PC-12
Lane 4: Mouse heart tissue
Lane 5: Hela
Recombinant Rabbit monoclonal primary
Recombinant HuR ELAVL1 Monoclonal Antibody (ET1705-81)
Rat spleen tissue, rat heart tissue, PC-12, Mouse heart tissue, Hela, Jurkat, rat lung tissue, human colon cancer tissue, human breast tissue, mouse testis tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
ELAV-like protein 1
HuR, ELAVL1, HUR
Belongs to the RRM elav family.
Ubiquitous. Detected in brain, liver, thymus and muscle.
Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD.; Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
Cytoplasm. Nucleus. Cytoplasm, Stress granule.
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.