UNIPROT #

Q15717

PROTEIN NAME

HuR ELAVL1

SYNONYMS

ELAV (embryonic lethal abnormal vision Drosophila) like 1 antibody; ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R) antibody; ELAV like 1 antibody; ELAV like RNA binding protein 1 antibody; ELAV-like protein 1 antibody; ELAV1 antibody; ELAV1_HUMAN antibody; Elavl1 antibody; Embryonic lethal abnormal vision drosophila homolog like 1 antibody; Hu Antigen R antibody; Hu-antigen R antibody; Hua antibody; HuR antibody; MelG antibody

SEQUENCE SIMILARITIES

Belongs to the RRM elav family.

TISSUE SPECIFICITY

Ubiquitous. Detected in brain, liver, thymus and muscle.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD.; Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.