Lane 1: SW480 cell lysate
Lane 2: SKOV-3 cell lysate
Lane 2: HepG2 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant HE4 Monoclonal Antibody (ET1702-61)
SW480 cell lysate, SKOV-3 cell lysate, HepG2 cell lysate, SKOV-3, SW480, mouse lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
dJ461P17.6 antibody; EDDM4 antibody; epididymal protein 4 antibody; Epididymal secretory protein E4 antibody; Epididymis specific whey acidic protein type four disulfide core antibody; HE 4 antibody; Major epididymis specific protein E4 antibody; Major epididymis-specific protein E4 antibody; MGC57529 antibody; Putative protease inhibitor WAP5 antibody; WAP 5 antibody; WAP domain containing protein HE4 antibody; WAP domain containing protein HE4 V4 antibody; WAP four disulfide core domain 2 antibody; WAP four disulfide core domain protein 2 antibody; WAP four-disulfide core domain protein 2 antibody; WAP5 antibody; WFDC 2 antibody; WFDC2 antibody; WFDC2_HUMAN antibody
Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
HE4 (whey acidic protein (WAP)-type four-disulfide core-2, WFDC2) is a small secretory protein that may influence sperm maturation. HE4 gene expression is high in pulmonary epithelial cells and in some ovarian cancers. HE4 protein has a WAP motif that contains eight cysteines forming four disulfide bonds at the core of the protein. The WAP motif functions as a protease inhibitor in many of the family members that contain them.