Lane 1: 293T cell lysate
Lane 2: K562 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant HDAC2 Monoclonal Antibody (ET1607-78)
293T cell lysate, K562 cell lysate, Hela, SHG-44, 293, rat spinal cord tissue, human tonsil tissue, human breast carcinoma tissue, mouse spinal cord tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
D10Wsu179e antibody; HD 2 antibody; HD2 antibody; HDAC 2 antibody; Hdac2 antibody; HDAC2_HUMAN antibody; Histone deacetylase 2 (HD2) antibody; Histone deacetylase 2 antibody; OTTHUMP00000017046 antibody; OTTHUMP00000227077 antibody; OTTHUMP00000227078 antibody; RPD3 antibody; transcriptional regulator homolog RPD3 antibody; YAF1 antibody; YY1 associated factor 1 antibody; YY1 transcription factor binding protein antibody; Yy1bp antibody
Belongs to the histone deacetylase family. HD type 1 subfamily.
Widely expressed; lower levels in brain and lung.
S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1) and HDAC2 (also designated mammalian RPD3), both of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
Tang, Tianxiang et al.
HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development. | Neuron 
Wang, Hao et al.
Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells. | Oncology Letters