UNIPROT #

P42261

PROTEIN NAME

Glutamate receptor 1

SYNONYMS

GLUR 1 antibody; GLUR A antibody; AMPA 1 antibody; AMPA selective glutamate receptor 1 antibody; AMPA-selective glutamate receptor 1 antibody; GluA1 antibody; GLUH1 antibody; GluR K1 antibody; GluR-1 antibody; GluR-A antibody; GluR-K1 antibody; GLUR1 antibody; GLURA antibody; GluRK1 antibody; Glutamate receptor 1 antibody; Glutamate receptor ionotropic AMPA 1 antibody; Glutamate receptor ionotropic antibody; Glutamate receptor, ionotropic, AMPA 1 antibody; Gria1 antibody; GRIA1_HUMAN antibody; HBGR1 antibody; MGC133252 antibody; OTTHUMP00000160643 antibody; OTTHUMP00000165781 antibody; OTTHUMP00000224241 antibody; OTTHUMP00000224242 antibody; OTTHUMP00000224243 antibody

SEQUENCE SIMILARITIES

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.

TISSUE SPECIFICITY

Widely expressed in brain.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).; Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).

SUBCELLULAR LOCATION

Cell membrane, postsynaptic cell membrane, postsynaptic density membrane, Endoplasmic reticulum membrane, Early endosome membrane, Recycling endosome membrane, dendrite, dendritic spine.

FUNCTION

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.