Recombinant Rabbit monoclonal primary
Recombinant GLUT2 Monoclonal Antibody (ET1701-34)
MCF-7, Hela, HepG2, human liver tissue, human pancreas tissue, human kideny tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
liver antibody; Glucose Transporter 2 antibody; Glucose Transporter GLUT2 antibody; Glucose transporter type 2 antibody; Glucose transporter type 2 liver antibody; Glucose transporter, liver/islet antibody; GLUT-2 antibody; GLUT2 antibody; GTR2_HUMAN antibody; GTT2 antibody; SLC2A2 antibody; Solute carrier family 2 (facilitated glucose transporter) member 2 antibody; Solute carrier family 2 facilitated glucose transporter member 2 antibody; Solute carrier family 2, facilitated glucose transporter member 2 antibody
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Liver, insulin-producing beta cell, small intestine and kidney.
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. Glut1, Glut3 and Glut4 are high-affinity transporters, whereas Glut2 is a low-affinity transporter. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to insulin. Glut2 expression is seen in pancreatic beta cells, hepatocytes and basolateral membranes of intestinal and epithelial cells, while the highest expression of Glut3 has been found in neuronal tissue.