Recombinant Rabbit monoclonal primary
Recombinant GIT1 Monoclonal Antibody (ET7106-91)
Rat brain tissue, human colon cancer tissue, human pancreas tissue, mouse fallopian tubes tissue, A549.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
ARF GAP GIT1 antibody; ARF GTPase activating protein GIT1 antibody; ARF GTPase-activating protein GIT1 antibody; CAT 1 antibody; CAT-1 antibody; CaT1 antibody; Cool associated and tyrosine phosphorylated protein 1 antibody; Cool-associated and tyrosine-phosphorylated protein 1 antibody; G protein coupled receptor kinase interacting ArfGAP 1 antibody; G protein coupled receptor kinase interactor 1 antibody; G protein-coupled receptor kinase-interactor 1 antibody; GIT1 antibody; GIT1_HUMAN antibody; GRK interacting protein 1 antibody; GRK-interacting protein 1 antibody
Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase (By similarity).
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling.