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PRODUCT CODE: ET1703-32

Recombinant GBA Monoclonal Antibody (ET1703-32)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Rat

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Western blot analysis of GBA on diffewrent cells lysates using anti-GBA antibody at 1/1,000 dilution.<br /> Positive control:<br /> Lane 1: HepG2<br /> Lane 2: 293T
  • Western blot analysis of GBA on diffewrent cells lysates using anti-GBA antibody at 1/1,000 dilution.<br /> Positive control:<br /> Lane 1: HepG2<br /> Lane 2: 293T
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-GBA antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-GBA antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-GBA antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-GBA antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-GBA antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-GBA antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue using anti-GBA antibody. Counter stained with hematoxylin.
Western blot analysis of GBA on diffewrent cells lysates using anti-GBA antibody at 1/1,000 dilution.
Positive control:
Lane 1: HepG2
Lane 2: 293T

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant GBA Monoclonal Antibody (ET1703-32)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

SK-Br-3 cell lysate, A549 cell lysate, MCF-7 cell lysate, human breast carcinoma tissue, human liver tissue, human pancreas tissue, human kidney tissue, rat liver tissue, rat kidney tissue, mouse pancreas tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM10-76

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A affinity purified.

MOLECULAR WEIGHT

60 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

P04062

PROTEIN NAME

GBA

SYNONYMS

Acid beta glucosidase antibody; Acid beta-glucosidase antibody; Alglucerase antibody; Beta glucocerebrosidase antibody; BETA GLUCOSIDASE, ACID antibody; Beta-glucocerebrosidase antibody; betaGC antibody; D glucosyl N acylsphingosine glucohydrolase antibody; D-glucosyl-N-acylsphingosine glucohydrolase antibody; EC 3.2.1.45 antibody; GBA antibody; Gba protein antibody; GBA1 antibody; GC antibody; GCase antibody; GCB antibody; GLCM_HUMAN antibody; GLUC antibody; Glucocerebrosidase (alt.) antibody; Glucocerebrosidase antibody; GLUCOCEREBROSIDASE PSEUDOGENE antibody; Glucosidase beta antibody; Glucosidase, beta, acid antibody; Glucosidase, beta; acid (includes glucosylceramidase) antibody; Glucosylceramidase antibody; Imiglucerase antibody; Lysosomal glucocerebrosidase antibody; OTTHUMP00000033992 antibody; OTTHUMP00000033993 antibody

SEQUENCE SIMILARITIES

Belongs to the glycosyl hydrolase 30 family.

SUBCELLULAR LOCATION

Lysosome membrane.

FUNCTION

β-Glucosidase is a predominantly liver enzyme which efficiently hydrolyzes β-D-glucoside and β-D-galactoside. Defects in β-glucosidase cause Gaucher disease, an inherited condition distinguished by the accumulation of glucosylceramide within the cells of the reticuloendothelial system. β-Glucosidase is used in enzyme replacement treatment aimed at treating Gaucher disease. The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial β-glucosidases.