Lane 1: Human fetal brain tissue
Lane 2: HepG2
Lane 3: 293
Recombinant Rabbit monoclonal primary
Recombinant FTO Monoclonal Antibody (ET1705-89)
Human fetal brain tissue lysate, HepG2, 293, human placenta tissue, human pancreas tissue, human uterus tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
AlkB homolog 9 antibody; ALKBH9 antibody; Alpha-ketoglutarate-dependent dioxygenase FTO antibody; AW743446 antibody; Fat mass and obesity-associated protein antibody; FATSO, MOUSE, HOMOLOG OF antibody; Fto antibody; FTO_HUMAN antibody; GDFD antibody; KIAA1752 antibody; mKIAA1752 antibody; Protein fatso antibody
Belongs to the fto family.
Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. Highly expressed in highly expressed in acute myeloid leukemias (AML) with t(11;11)(q23;23) with KMT2A/MLL1 rearrangements, t(15;17)(q21;q21)/PML-RARA, FLT3-ITD, and/or NPM1 mutations.
FTO, also known as Fatso or KIAA1752, is a 505 amino acid protein that has an N-terminal nuclear localization signal. Expressed in a variety of tissues, with highest levels present in brain and pancreatic tissue, Fatso exists as four alternatively spliced isoforms, one of which is associated with a predisposition to childhood and adult obesity. Due to its involvement in the development of obesity, Fatso is associated with an increased BMI and may be involved in the pathogenesis of type 2 diabetes. The gene encoding Fatso maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.