Recombinant Rabbit monoclonal primary
Recombinant FosB Monoclonal Antibody (ET1611-75)
Human liver tissue lysates, human tonsil tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Activator protein 1 antibody; AP 1 antibody; DKFZp686C0818 antibody; FBJ murine osteosarcoma viral oncogene homolog B antibody; fosB antibody; FOSB_HUMAN antibody; G0/G1 switch regulatory protein 3 antibody; G0S3 antibody; GOS 3 antibody; GOS B antibody; GOS3 antibody; GOSB antibody; MGC42291 antibody; Oncogene FOS B antibody; Oncogene FOSB antibody; Protein fos B antibody; Protein fosB antibody
Belongs to the bZIP family. Fos subfamily.
The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.