Recombinant Rabbit monoclonal primary
Recombinant FAP1 Monoclonal Antibody (ET1704-23)
Recombinant protein within c-terminal of human fap1 aa 1-120.
Hela cell lysates, human colon carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
APO1/CD95 (Fas) associated phosphatase antibody; DKFZp686J1497 antibody; FAP 1 antibody; FAP1 antibody; Fas associated phosphatase 1 antibody; Fas associated protein tyrosine phosphatase 1 antibody; HGNC:9646 antibody; hPTPE1 antibody; Phosphatase rip antibody; PNP 1 antibody; PNP1 antibody; Protein tyrosine phosphatase 1 Fas associated antibody; protein tyrosine phosphatase 1E antibody; Protein tyrosine phosphatase non receptor type 13 antibody; Protein tyrosine phosphatase nonreceptor type 13 antibody; Protein tyrosine phosphatase PTPL1 antibody; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) antibody; PTP BAS antibody; PTP BL antibody; PTP E1 antibody; PTP1E antibody; PTPL 1 antibody; PTPL1 antibody; PTPLE antibody; PTPN 13 antibody; PTPN13 antibody; Tyrosine protein phosphatase non receptor type 13 antibody
Belongs to the peptidase S9B family.
Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
N-glycosylated.; The N-terminus may be blocked.
Cell membrane. Cell surface.
FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is co-localized with MMP-1and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.