Lane 1: K562
Lane 2: 293T
Lane 3: HepG2
Recombinant Rabbit monoclonal primary
Recombinant E2F2 Monoclonal Antibody (ET1611-88)
K562, 293T, HepG2.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Transcription factor E2F2
Belongs to the E2F/DP family.
Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.