Recombinant Rabbit monoclonal primary
Recombinant DUSP6 Monoclonal Antibody (ET1602-18)
Mouse pancreas tissue lysates, Hela, PC-12, NIH/3T3, human gastric carcinoma tissue, human pancreas tissue, mouse brain tissue, mouse pancreas tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Dual specificity protein phosphatase 6
MAP kinase phosphatase 3, MKP-3
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Expressed in keratinocytes (at protein level).
Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors.