Recombinant Rabbit monoclonal primary
Recombinant DRD1 Monoclonal Antibody (ET1703-45)
293T, N2A, SH-SY5Y, mouse kidney, mouse brain tissue, rat brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
D(1A) dopamine receptor antibody; D1A dopamine receptor antibody; DADR antibody; Dopamine D1 receptor antibody; dopamine receptor D1 antibody; DR D1 antibody; DR D1A antibody; DRD 1 antibody; DRD 1A antibody; DRD1 antibody; DRD1_HUMAN antibody; DRD1A antibody
Belongs to the G-protein coupled receptor 1 family.
Detected in caudate, nucleus accumbens and in the olfactory tubercle.
Cell membrane. Endoplasmic reticulum membrane.
The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. β-adrenergic receptor binds to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor binds to adrenaline inhibits adenylyl cyclase. The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics in that D1 receptors stimulate adenylyl cyclase while D2 receptors inhibit adenylyl cyclase activity. Five different subtypes of dopamine receptor have been described to date. D1DR and D5DR belong to the D1 subclass, while D2DR, D3DR and D4DR belong to the D2 subclass.