UNIPROT #

O14763

PROTEIN NAME

DR5

SYNONYMS

Fas like protein antibody; Apoptosis inducing protein TRICK2A/2B antibody; Apoptosis inducing receptor TRAIL R2 antibody; CD262 antibody; CD262 antigen antibody; Cytotoxic TRAIL receptor 2 antibody; Death domain containing receptor for TRAIL/Apo 2L antibody; Death receptor 5 antibody; DR5 antibody; KILLER antibody; KILLER/DR5 antibody; OTTHUMP00000123492 antibody; OTTHUMP00000123493 antibody; p53 regulated DNA damage inducible cell death receptor(killer) antibody; TNF related apoptosis inducing ligand receptor 2 antibody; TNF-related apoptosis-inducing ligand receptor 2 antibody; TNFRSF10B antibody; TR10B_HUMAN antibody; TRAIL R2 antibody; TRAIL receptor 2 antibody; TRAIL-R2 antibody; TRAILR2 antibody; TRICK2 antibody; TRICK2A antibody; TRICK2B antibody; TRICKB antibody; Tumor necrosis factor receptor like protein ZTNFR9 antibody; Tumor necrosis factor receptor superfamily member 10B antibody; Tumor necrosis factor receptor superfamily, member 10b antibody; ZTNFR9 antibody

TISSUE SPECIFICITY

Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the "death domain," that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.