UNIPROT #

P41143

PROTEIN NAME

Delta Opioid Receptor

SYNONYMS

D-OR-1 antibody; Delta type opioid receptor antibody; Delta type opioid receptor DOR 1 antibody; Delta type opioid receptor DOR1 antibody; Delta-type opioid receptor antibody; DOR 1 antibody; DOR-1 antibody; DOR1 antibody; mDOR antibody; Nbor antibody; Opioid receptor delta 1 antibody; OPRD 1 antibody; OPRD antibody; OPRD_HUMAN antibody; Oprd1 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.; Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins. The three opioid receptor types are highly homologous and belong to the superfamily of G protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.