Positive control:
Lane 1: HUVEC
Lane 2: Rat brain
Applications
-
WB
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Recombinant Delta Opioid Receptor Monoclonal Antibody (ET1611-92)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
HUVEC cell lysate, rat brain tissue lysate, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SN20-04
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A affinity purified.
MOLECULAR WEIGHT
40 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:1,000
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
Delta Opioid Receptor
SYNONYMS
D-OR-1 antibody; Delta type opioid receptor antibody; Delta type opioid receptor DOR 1 antibody; Delta type opioid receptor DOR1 antibody; Delta-type opioid receptor antibody; DOR 1 antibody; DOR-1 antibody; DOR1 antibody; mDOR antibody; Nbor antibody; Opioid receptor delta 1 antibody; OPRD 1 antibody; OPRD antibody; OPRD_HUMAN antibody; Oprd1 antibody
SEQUENCE SIMILARITIES
Belongs to the G-protein coupled receptor 1 family.
TISSUE SPECIFICITY
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
POST-TRANSLATIONAL MODIFICATION
N-glycosylated.; Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
SUBCELLULAR LOCATION
Cell membrane.
FUNCTION
Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins. The three opioid receptor types are highly homologous and belong to the superfamily of G protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.